Senior Backend Engineer, AI & Bioinformatics (TypeScript)

Senior Backend Engineer blending AI backend engineering and human bioinformatics to design and build production AI systems that reason over whole genome our client data. The role involves building distributed services, genomic reasoning engines, retrieval systems, and high-performance data platforms to enable accurate, explainable genomic AI.

• Design and build production AI systems, distributed backend services, and genomic reasoning engines
• Develop retrieval systems and data platforms combining bioinformatics with modern AI
• Serve as the bioinformatics expert on the AI Team to shape genomic knowledge representation and validation
• Design high-performance data models, indexing strategies, and storage across PostgreSQL, Qdrant, Redis, DuckDB, and Apache Spark
• Develop guardrails and deterministic reasoning layers to ensure scientifically accurate AI responses
• Collaborate with Senior Backend Engineers and the Bioinformatics team to integrate annotations and interpretation logic

• TypeScript
• Bioinformatics
• Distributed Systems
• Apache Spark
• PostgreSQL
• DuckDB
• Redis
• Message Queues

Preferred: • Work on novel AI platform that reasons over whole human genomes at scale

• Combine cutting-edge AI (LLMs, retrieval, vector DBs) with clinical-grade genomics
• Fully remote role at a profitable, venture-backed company building category-defining products

15 DAYS PTO, US holidays

our client.com (legal name: our client Inc.) is a Pasadena, California-based healthtech company founded in 2014 that has built a DNA testing and analysis platform enabling personalized healthcare tailored to an individual's genome. Their core mission is to help people "outsmart their genes" by providing free, unlimited storage of DNA data along with tools and reports that translate raw genetic data into actionable health insights.