Variant Curator

The Variant Curator reviews and classifies genetic variants to ensure accurate interpretation for customers, analyzes raw genomic data to support inquiries and troubleshooting, and refines variant classification methodologies including AI-driven approaches. The role supports ClinVar submissions and enhances database associations to improve variant annotation and clinical insight.

Review variant reports for inconsistencies in variant calling and data interpretation.
Investigate and classify variants associated with conditions that have not yet been submitted to ClinVar.
Enhance the value of ClinVar data by associating unclassified variants with known conditions.
Analyze raw genetic data files to support customer inquiries and troubleshooting.
Contribute to the development and refinement of AI prompts for improved genetic accuracy in AI-driven variant interpretation.

2+ years experience with variant classification and genomic databases (ClinVar, gnomAD, HGMD).
Familiarity with NGS data analysis and raw genetic data interpretation.
Strong analytical skills and attention to detail.
Excellent written and verbal communication skills.
Experience in clinical variant interpretation or curation.
Excellent problem-solving skills, attention to detail, and ability to work independently.
Knowledge of Python or R for data analysis.
Experience with bug tracking and Agile tools such as JIRA and Confluence.
Benefits Overview
Comprehensive medical, dental, and vision insurance coverage
401(k) with company matching
Paid time off (PTO)
Paid volunteer time off
Fully remote work with home office stipend
Parental bonding leave
Clinical-grade whole genome our client for you and your family (private and confidential)
Join our client
Redefine how people understand themselves through their DNA
Build category-defining products alongside scientists, engineers, and innovators
Contribute to technology that will improve and extend millions of lives
Shape one of the most important emerging categories in AI and healthcare
our client Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process.

Preferred: • Work on the world’s largest direct-to-consumer whole genome our client platform

• Contribute to AI-powered personalized health products with clinical-grade genomes
• Fully remote role at a profitable, venture-backed company with family our client benefits

Education: Associate's in IT